Kratom is a natural pain killer, and its popularity is growing worldwide due to this feature. Around three to five million US people use this substance for numerous reasons. There are over twelve variants of kratom, each with unique properties; some are sedative other acts as stimuli. Some variants have strong painkiller properties, while others are consumed for mood enhancers and euphoria. Chiefly there are three classes; red vein, known for its powerful anti-pain property; green vein, which inherits the same property but with less intensity. The white vein is used more as a nootropic stimulant.
Red vein kratom
The red vein is more commonly used as a painkiller, other variants have a medical properties for pain management, but the red vein has a strong anti-pain aspect. Red vein kratom is an analgesic; unlike an anesthetic, it does not make you unconscious but changes the perception of surroundings or affects consciousness. It primarily blocks pain signals transmitted to the brain or impacts the brain’s reading to those pain impulses. It also improves sleep quality and pattern and may reduce anxiety or depression.
Red Bali is the best Kratom for pain relief as it acts as a powerful stimulant rather than a sedative. Its strong stimulant property helps you fight pain throughout the day while you venture into other activities. Testimonials of users and pre and early clinical studies show alkaloid content in kratom is beneficial for treating pain, managing substance abuse, and elevating mood and mental health conditions. Simultaneously there are reports about the side effects of Kratom use; these two extreme aspects often become a topic of discussion.
The interest of the scientific community
Earlier, Kratom was used in Southeast Asia, particularly in Malaysia and Thailand, to treat minor pain and to increase work capability. It was a substitute for opium in the 1930s, but its usage spread to the west, particularly in the US. It is used more as over-the-counter medicine to treat acute and chronic pain or refrain from non-prescribed opioids. It also treats mental disorders like anxiety, depression, and traumatic stress. The use of Kratom is not limited to Southeast Asia; it has increased the interest of the scientific community to probe into the therapeutic potential of Kratom and its potential side effects.
Kratom alkaloids metabolism
Metabolism flushes out traces of the drug from the animal and human body by transforming it into water-soluble metabolites. The process undergoes two phases; in the first stage, oxidation, reduction reaction, and hydrolysis occur, followed by sulfation and glucuronidation. But the Kratom alkaloids metabolism pathway is still unclear. Despite the inadequate data, Kratom for pain relief is beneficial when administered in moderate dosage.